This section is intended for UK healthcare professionals. If you are a member of the public click here. If you have been prescribed Ninlaro click here.

Administration

How to administer NINLARO1

The usual recommended starting dose of oral NINLARO is one 4 mg capsule taken once a week with lenalidomide and dexamethasone at standard dosing1

Each dose of NINLARO should be taken approximately the same time each day on an empty stomach (at least 1 hour before or at least 2 hours after food)1 ‡

  • Because dexamethasone should be taken with food, NINLARO and dexamethasone should not be taken at the same time

NINLARO should be swallowed whole with a glass of water - the capsule should not be crushed, chewed or opened1

  • If a patient vomits after taking a dose, the patient should not repeat the dose but should resume dosing at the time of the next scheduled dose§

If a dose of NINLARO is delayed or missed, the dose should be taken only if the next scheduled dose is ≥72 hours away1

  • A missed dose should not be taken within 72 hours of the next scheduled dose
  • A double dose should not be taken to make up for a missed dose

NINLARO should be stored in the original packaging in order to protect from moisture¤ and the capsules should be removed just prior to dosing1 - this means they cannot be transferred to a pill box

Do not store above 30°C. Do not freeze1

NINLARO is cytotoxic - direct contact with the capsule contents should be avoided

Administration with a high-fat meal decreased ixazomib AUC by 28% compared with administration after an overnight fast

§ After oral administration, peak plasma concentrations of ixazomib were achieved at approximately one hour after dosing

¤ Ixazomib citrate, a prodrug, is a substance that rapidly hydrolyses under physiological conditions to its biologically active form, ixazomib

NINLARO Patient Support Programme (PSP)

This NINLARO Patient Support Programme (PSP) has been designed to help patients familiarise themselves with the NINLARO based triplet regimen. The programme is intended for patients that are currently receiving or are about to initiate treatment with the NINLARO regimen.

To download a copy of the booklet, which provides further information on the programme for Healthcare Professional click here

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